On the nature and effect of power distribution noise in CMOS digital integrated circuits

The thesis reports on the development of a novel simulation method aimed at modelling power distribution noise generated in digital CMOS integrated circuits. The simulation method has resulted in new information concerning: 1. The magnitude and nature of the power distribution noise and its dependence on the performance and electrical characteristics of the packaged integrated circuit. Emphasis is laid on the effects of resistive, capacitative and inductive elements associated with the packaged circuit. 2. Power distribution noise associated with a generic systolic array circuit comprising 1,020,000 transistors, of which 510,000 are synchronously active. The circuit is configured as a linear array which, if fabricated using two-micron bulk CMOS technology, would be over eight centimetres long and three millimetres wide. In principle, the array will perform 1.5 x 10 to the power of 11 operations per second. 3. Power distribution noise associated with a non-array-based signal processor which, if fabricated in 2-micron bulk CMOS technology, would occupy 6.7 sq. cm. The circuit contains about 900,000 transistors, of which 600,000 are functional and about 300,000 are used for yield enhancement. The processor uses the RADIX-2 algorithm and is designed to achieve 2 x 10 to the power of 8 floating point operations per second. 4. The extent to which power distribution noise limits the level of integration and/ or performance of such circuits using standard and non-standard fabrication and packaging technology. 5. The extent to which the predicted power distribution noise levels affect circuit susceptibility to transient latch-up and electromigration. It concludes the nature of CMOS digital integrated circuit power distribution noise and recommends ways in which it may be minimised. It outlines an approach aimed at mechanising the developed simulation methodology so that the performance of power distribution networks may more routinely be assessed. Finally. it questions the long term suitability of mainly digital techniques for signal processing

Dynamics of Dense Cores in the Perseus Molecular Cloud

We survey the kinematics of over one hundred and fifty candidate (and potentially star-forming) dense cores in the Perseus molecular cloud with pointed N2H+(1-0) and simultaneous C18O(2-1) observations. Our detection rate of N2H+ is 62%, rising to 84% for JCMT SCUBA-selected targets. In agreement with previous observations, we find that the dense N2H+ targets tend to display nearly thermal linewidths, particularly those which appear to be starless (using Spitzer data), indicating turbulent support on the small scales of molecular clouds is minimal. For those N2H+ targets which have an associated SCUBA dense core, we find their internal motions are more than sufficient to provide support against the gravitational force on the cores. Comparison of the N2H+ integrated intensity and SCUBA flux reveals fractional N2H+ abundances between 10^-10 and 10^-9. We demonstrate that the relative motion of the dense N2H+ gas and the surrounding C18O gas is less than the sound speed in the vast majority of cases (~90%). The point-to-point motions we observe within larger extinction regions appear to be insufficient to provide support against gravity, although we sparsely sample these regions.Comment: 49 pages, 20 figures. Accepted for publication in the Astrophysical Journa

A Submillimeter Array Survey of Protoplanetary Disks in the Orion Nebula Cluster

We present the full results of our 3-year long Submillimeter Array survey of protoplanetary disks in the Orion Nebula Cluster. We imaged 23 fields at 880 microns and 2 fields at 1330 microns, covering an area of ~6.5 arcmin^2 and containing 67 disks. We detected 42 disks with fluxes between 6-135 mJy and at rms noise levels between 0.6 to 5.3 mJy/beam. Thermal dust emission above any free-free component was measured in 40 of the 42 detections, and the inferred disk masses range from 0.003-0.07 Msolar. We find that disks located within 0.3 pc of theta^1 Ori C have a truncated mass distribution, while disks located beyond 0.3 pc have masses more comparable to those found in low-mass star forming regions. The disk mass distribution in Orion has a distance dependence, with a derived relationship max(M_(disk)) = 0.046Msolar(d/0.3pc)^0.33 for the maximum disk masses. We found evidence of grain growth in disk 197-427, the only disk detected at both 880 microns and 1330 microns with the SMA. Despite the rapid erosion of the outer parts of the Orion disks by photoevaporation, the potential for planet formation remains high in this massive star forming region, with approximately 18% of the surveyed disks having masses greater than or equal to 0.01 Msolar within 60 AU.Comment: Accepted for publication in ApJ, 36 pages, 10 figure

Electrical Characterization of GaSb Based Semiconductors for 2-4 micrometers Diode Laser Applications

Deep Level Transient Spectroscopy (DLTS) was used to characterize the band offsets and deep levels in MBE grown GaSb-based semiconductors that are used in 2-4 µm laser diode structures. One of several deep level traps found in AlxGa1-xAsySb1-y (x=0, 0.5, 0.6, 1.0) is a GaSb double acceptor trap. Progress is also made in establishing the model for the DX center in this material. The degree of compensation of the donor related DX center by GaSb affect where donors are situated, giving preference to one configuration over the many other possible configurations. One minority trap 320 meV below the conduction band, and six hole traps 24, 76, 108, 122, 224, and 276 meV above the valence band were found in the Ga0.85In0.15As0.12Sb0.88 using DLTS measurements. It is believed that the minority trap level at 320 meV and the hole trap level at 276 meV originate from the same trap, making it the most efficient non-radiative recombination center. Extrapolating a series of quantum well emission energies measured by DLTS (based on Boltzmann\u27s approximation) to a point where the approximation is valid, results in a valence band offset of 0.52 eV between Ga0.81In0.19As0.12Sb0.88 and Al0.9Ga0.1AsSb lattice matched to GaSb

Enhancing Small Group Teaching in Plant Sciences: A Research and Development Project in Higher Education

The Department of Plant Sciences at the University of Cambridge uses a range of learning and teaching environments including lectures, practical laboratories and small group tutorials'. Under the auspices of the Cambridge-MIT Institute's Pedagogy Programme, a two-year research and development project concerned with the development of small-group teaching is being undertaken. The research element of this project endeavours to illuminate current practice and identify areas in which evidence-based development might take place. The development element will include professional development activities and the production of curriculum resources including appropriate online material. This is a multi-method study including a series of student questionnaires; focus groups of students; semi-structured interviews with staff members; and the collection of video of small group teaching. In this paper we report selected findings from the 'student data' of the first year of this project.The questionnaire, conducted with two cohorts of students (2nd and 3rd year Undergraduates), used a double-scale questionnaire in which students were asked to report both on the prevalence of a range of teaching and learning practices and on how valuable these were in supporting their learning. This type of questionnaire instrument is particularly appropriate because the data it generates is suggestive of areas for changes in practice. The gaps between 'practices' and 'values' (across both cohorts) suggested that students valued activities which improved their understanding of how elements of the course were interrelated; which related course content to 'authentic' examples; and those in which teachers made explicit the characteristics of 'high quality' student work. Small group teaching, in the view of most students, was best used to extend and explore concepts introduced in lectures rather than simply reinforcing them or assessing student understanding.Data gathered through focus group activities illuminated the questionnaire data, providing detailed accounts of how students managed their own learning, and the roles played in this by lectures, small group teaching and other resources. Students identified the processes of planning and writing essays as key learning activities during which they integrated diverse course content and reflected on problematic knowledge. Questionnaire and focus group data suggested that students had less clear views regarding the value of collaborative learning, peer-assessment or activities such as making presentations to other students. When students talked in positive terms about these activities, they often referred to the learning benefits of preparation for the tasks rather than of the collaborative activities themselves. These views may provide indications of potential barriers to changes in learning and teaching environments, and suggest that any such changes may have to be carefully justified to students in terms of benefits to their own learning. Many of our findings are broadly in accord with other work on teaching and learning in Higher Education settings (such as the 'Oxford Learning Context Project' and the 'Enhancing Teaching-Learning Environments in Undergraduate Courses' Project) in that 'deep learning' and 'authenticity' in learning activities are valued by students, and that the introduction of specific formative practices (such as sharing notions of 'quality') would be welcomed. At the same time, amongst the students in our sample, a view of learning as an individual process of 'learning-as-acquisition' predominates over a view that it is a social process of 'learning-as-participation', and this will inform the planning of the 'development' aspect of the project. We conclude with a discussion of how the approach we have used might be more widely applied both within and beyond the Cambridge-MIT partnership. We also identify potential affordances of, and barriers to, the development of research-informed teaching in Higher Education

Gas sensing based on optical fibre coupled diode laser spectroscopy : a new approach to sensor systems for safety monitoring

We describe an entirely passive fibre optic network which senses, amongst other species, CH¬4¬ and CO¬¬2 , with sensitivity and selectivity compatible with safety sensing in the mine environment. The basic principle is that a single laser diode source targeted to a particular species addresses up to 200 sensing points which may be spread over an area of dimensions ten or more km. The detection and processing electronics is typically located with the laser source. Several laser sources can be introduced in parallel to enable monitoring multiple species. The network itself, entirely linked through optical fibre, is inherently intrinsically safe. It is self checking for faults at the sensing location and continuously self calibrating. In the methane sensing mode its sensitivity is sub 100ppm and it responds accurately up to 100% methane. It is therefore capable of detecting extremely hazardous gas pockets which are completely missed by other sensor technologies. The network has demonstrated stability with zero maintenance or recalibration over periods in excess of two years. We believe that this system offers unique benefits in the context of mine safety and ventilation system monitoring

CW high intensity non-scaling FFAG proton drivers

Accelerators are playing increasingly important roles in basic science, technology, and medicine including nuclear power, industrial irradiation, material science, and neutrino production. Proton and light-ion accelerators in particular have many research, energy and medical applications, providing one of the most effective treatments for many types of cancer. Ultra high-intensity and high-energy (GeV) proton drivers are a critical technology for accelerator-driven sub-critical reactors (ADS) and many HEP programs (Muon Collider). These high-intensity GeV-range proton drivers are particularly challenging, encountering duty cycle and space-charge limits in the synchrotron and machine size concerns in the weaker-focusing cyclotrons; a 10-20 MW proton driver is not presently considered technically achievable with conventional re-circulating accelerators. One, as-yet, unexplored re-circulating accelerator, the Fixed-field Alternating Gradient, or FFAG, is an attractive alternative to the cyclotron. Its strong focusing optics are expected to mitigate space charge effects, and a recent innovation in design has coupled stable tunes with isochronous orbits, making the FFAG capable of fixed-frequency, CW acceleration, as in the classical cyclotron. This paper reports on these new advances in FFAG accelerator technology and references advanced modeling tools for fixed-field accelerators developed for and unique to the code COSY INFINITY.Comment: 3 pp. Particle Accelerator, 24th Conference (PAC'11) 2011. 28 Mar - 1 Apr 2011. New York, US

Connexins: synthesis, post-translational modifications, and trafficking in health and disease

Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to these proteins. The connexin gene family is under extensive regulation at the transcriptional and post-transcriptional level, and undergoes numerous modifications at the protein level, including phosphorylation, which ultimately affects their trafficking, stability, and function. Here, we summarize these key regulatory events, with emphasis on how these affect connexin multifunctionality in health and disease

ASCA and ROSAT observations of nearby cluster cooling flows

We present a detailed analysis of the X-ray properties of the cooling flows in a sample of nearby, X-ray bright clusters of galaxies using high-quality ASCA spectra and ROSAT X-ray images. We demonstrate the need for multiphase models to consistently explain the spectral and imaging X-ray data for the clusters. The mass deposition rates of the cooling flows, independently determined from the ASCA spectra and ROSAT images, exhibit reasonable agreement. We confirm the presence of intrinsic X-ray absorption in the clusters using a variety of spectral models. We also report detections of extended $100\mu$m infrared emission, spatially coincident with the cooling flows, in several of the systems studied. The observed infrared fluxes and flux limits are in good agreement with the predicted values due to reprocessed X-ray emission from the cooling flows. We present precise measurements of the abundances of iron, magnesium, silicon and sulphur in the central regions of the Virgo and Centaurus clusters. Our results firmly favour models in which a high mass fraction (70-80 per cent) of the iron in the X-ray gas in these regions is due to Type Ia supernovae. Finally, we present a series of methods which may be used to measure the ages of cooling flows from the X-ray data. The results for the present sample of clusters indicate ages of between 2.5 and 7 Gyr. If the ages of cooling flows are primarily set by subcluster merger events, then our results suggest that in the largest clusters, mergers with subclusters with masses of approximately 30 per cent of the final cluster mass are likely to disrupt cooling flows.Comment: Final version. MNRAS, in press. 36 pages, 9 figs, 14 tables in MNRAS LaTex styl